A personal thought I've had for a very long time was on the subject of alternate universes in videogames, where the villain character was the hero and the her character was the villain. Delta and Blaze helped me out with the designs for many of these characters, so credit to them for a lot of the lineart on these!
This is Doctor Andross, based on the psychic ape from Star Fox, with some designs choices based on Mega Man's Doctor Light.