Short explanation behind this one. GISHWHES is a crazy international scavenger hunt that is "go do" rather than "go find". Some of the items are doing-good-things sort of tasks, others are really odd art challenges.
Clearly, this is one of the latter :P The item in question asked for an animal/human hybrid of one of the named actors, give your creation a punny name and then tweet the result to the actor in question. Undoubtedly one of the most unsettling things I've drawn, but I hope I made Misha laugh.
Used a few different photo references from Google to get the body to look right.