Neurotoxins: Most evident due to his body tightly integrated nervous system, Neurotoxins are the most fatal method employed by opponents should they choose to use it. Ace's physiology renders him completely dependent on a specific set of neurological actions that keep his mind and body in homeostasis and allows him to use his abilities. When disturbed the mind and body conflict with each other, causing systems to fail, and more than likely the death of the afflicted.

EMP's: As with the previous statement, the most important organ and system is the brain. It compared to many other species is wildly active exceeding many capabilities and spreading influence beyond itself. It is still electrical such as others, so excess activity is usually funneled. In the case of EMP's a large sudden surge is not what the brain is accustomed to handling, leading to crippled behavior and sometimes death.

Cognitive Dissonance: This is a personal weapon used. It causes Emotion to intertwine into a logical conflict putting the mind away from any current activites or actions it may be performing, thus disrupting it. It will not cause death directly, but it can leave Ace open for attack, which itself can lead to death.

Trauma: Slow death or impairing over time. Although Ace's body is incredibly rigorous, any pain inflicted cannot be absorbed forever in a continuing or sudden fight. Damaging the nerves along his body can disrupt functions and confuse the mind. Over time damage may become detrimental and permanent. Death may occur, but often it is just impairing.