This was something I did a few months ago for my Digital Imaging class in college on Photoshop CS6. Here is Serenity looking over the horizon and looking towards Dark Eden, where the Elder God Eye is looking straight towards her behind the circular cloud-like dome. Enjoy.
(References/Sources used for the following on this Piece (Since it was required for the Digital Matte Painting assignment):
Elder God Eye: http://static.giantbomb.com/uploads/original/0/3661/492426-egeye.jpg
(Another Note: I'm also sticking to traditional work. But this one was worthy enough to post :-))
Serenity (c) me
Elder God Eye (c) Crystal Dynamcs/Edios/Square Enix Europe
Art (c) me