Once a man, a construction worker with a terrible home life, he was overtaken by otherworldly parasites, the "brain" being a small pink eye parasite (taken place inside his left eye socket) who essentially adopted Carlisle's persona once his own consciousness slipped away for good. Another major player is a large cyclopean brain-eating worm who appears to be at odds with the eye parasite.
With his internal anatomy dramatically altered to accommodate, his outward appearance hasn't changed as much, save for the tips of his fingers developing into calloused claws, as well as his teeth being replaced by egg cases that crack when reacting to blood and hatching larvae enter the victim's blood stream...
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BloodylocksBathory
I love how wonderfully horrible this character is.