Demona from the animated TV series Gargoyles. For some reason, when Hunter's Moon aired, I couldn't help but think of the human equivalent of bug spray when she created that genocidal chemical/magical hybrid concoction out of industrial cleaner... :B
openCanvas, Easy Paint Tool SAI.
(Also, in case it wasn't obvious - most of these I'm uploading ATM are, sadly, unfinished. I will get to them as I can...)