I recently got a question regarding what I will and will not draw. Here is the best response that I can give:
The fandom has such a long laundry list of subject matter that it's difficult to make a list of what I will/won't draw without forgetting something. I find it easier to ask commissioners to let me know what they're interested in having done so I can evaluate it. I also understand that some people are apprehensive about either being criticized about what they like or offending an artist with their request. If I do have to tell someone no I will not judge their particular taste and am only stating that their request is something I can't do.
That being said,let me try to answer your question as best I can.
Any gender/sexual orientation is fine as well as most fetishes. Guro, Scat, and hardcore vore are the only things that I can think of that would get a hard no. Some others might get an extra charge for being something I'm uncomfortable with drawing or because of complexity. In the past extra charges have been put on commissions containing futa (due to complexity) and diapers (uneasiness with subject matter).