For the upcoming 68th anniversary of Wile E's debut, the original Wile E makes a valid complaint about the modernized versions of himself, with the "Looney Tunes Show" version (right) and the "Wabbit" version (left).
Wile E. Coyote is (c) by Warner Bros.
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FatalSyndrome
I think they're mostly stylistic changes under someone else's art direction, as opposed to a full redesign.