I drew Clyde in Sai (which proved a bit of a compatibility struggle for the Genius Tablet) so I wanted to try out Photoshop. Things generally went a lot better except the tablet kept freaking out and exploding CS4. The line quality is improved and the buttons on the tablet generally work in photoshop, but I had to restart 3-4 times in the short time it took me to draw this as the pen would stop drawing (it would register in CS4 as drawing, but there was no visible line) or would refuse to use the brush and get stuck on the eraser for some reason.

I am going to try this baby out in a few more programs - overall, though, if your drawing tool of choice is Photoshop and you can tolerate occasional glitches, it does a pretty decent job.